منابع مشابه
Double-blind controlled study of primidone in essential tremor.
The main interest in this case is that the patient's fits started only towards the end of a prolonged period of lactation, during which calcium losses would be expected to increase.3 We speculate that lactation was a major factor in inducing the convulsions since it may have reduced an already low plasma calcium concentration to epileptogenic levels. A further possibility is that she had a fami...
متن کاملBenign familial tremor treated with primidone.
Primidone given to a patient for epilepsy produced an unexpected reduction in benign familial tremor. Over the next eight years the drug was therefore tried in a prospective study of 20 other patients with benign familial tremor alone. Of these, six could not tolerate the drug because of vertigo and nausea but 12 obtained a good response, which in some cases was dramatic. Investigations in two ...
متن کاملPrimidone in essential tremor of the hands and head: a double blind controlled clinical study.
Uncontrolled clinical studies have suggested that primidone may be effective in reducing essential tremor thus providing a valuable alternative to beta-adrenoreceptor antagonists which are currently the drugs of first choice. A double blind, placebo controlled trial of primidone in essential tremor of the hands and head was carried out using both clinical and objective methods of assessment. Pr...
متن کاملA comparison of primidone, propranolol, and placebo in essential tremor, using quantitative analysis.
The effects of placebo, propranolol and primidone were compared in 14 patients with essential tremor in a double blind, randomised, crossover study. Objective measures of tremor were obtained using an accelerometer with subsequent spectral analysis. Both propranolol (p less than 0.01) and primidone (p less than 0.01) gave significant improvement in tremor, but there was no significant differenc...
متن کاملNeuroanatomical Heterogeneity of Essential Tremor According to Propranolol Response
BACKGROUND Recent studies have suggested that essential tremor (ET) is a more complex and heterogeneous clinical entity than initially thought. In the present study, we assessed the pattern of cortical thickness and diffusion tensor white matter (WM) changes in patients with ET according to the response to propranolol to explore the pathogenesis underlying the clinical heterogeneity of ET. ME...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1981
ISSN: 0022-3050
DOI: 10.1136/jnnp.44.7.650